DTM&H · Core Wisdom

Let the incubation period do the work

A sieve you already own, if you take the exposure history.

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Revision aid, not clinical advice. This page is educational material written for exam preparation. It is not a substitute for the current guideline or for clinical judgement, and must not be relied on for the care of any individual. Always check up-to-date national guidance and verify independently before acting on anything here.

Tropical medicine looks like an impossible list of diseases until you notice that time does most of the sorting. Before you reach for a differential, pin down two dates: when exposure could have begun and when symptoms actually started. The interval between them quietly deletes half the list.

A rough working sieve:

  • Under about 10 days: dengue, chikungunya, rickettsial infection, other arboviral illness — and the everyday causes of fever that travel does not exempt you from.
  • Around 7–21 days: malaria (falciparum most often within a month), enteric fever, leptospirosis; acute schistosomiasis usually comes later, at 2–12 weeks.
  • Beyond a month: vivax and ovale malaria with their liver stages, tuberculosis, visceral leishmaniasis, amoebic liver abscess, chronic schistosomiasis. Viral haemorrhagic fevers, by contrast, are effectively excluded beyond 21 days from exposure — which is exactly why the exposure date matters so much.

The history that feeds the sieve is not “did you travel?” but the specifics: rural or urban, freshwater contact, mosquito bites by day or by night, unpasteurised milk, sexual contact, animal contact, healthcare contact, and what prophylaxis and vaccines were actually taken.

Exam habit

In any vignette, underline the dates first. Many stems are written so that the incubation window alone points at the answer.

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Written for revision for the DTM&H, and current at the time of writing. Not a substitute for the full guidance or your clinical judgement; always check current guidance for patient care.

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